Update 9:58 p.m.
Police have confirmed to KSFY that the driver of the "striking vehicle" ran from the scene, injured. Several witnesses followed him and he was apprehended by police near the corner of 1st Avenue and 24th Street. He and the male driver of the motorcycle involved remain hospitalized Wednesday night.
Police say they do not believe alcohol was involved. No word yet on any charges that will be filed as a result of the accident.
Officers were at the intersection until 8:30 Wednesday night collecting evidence.
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Five vehicles were involved in an accident in one of Sioux Falls' busiest intersections. It happened at 5:50 Wednesday evening at 26th Street and Minnesota Avenue.
According to Sgt. Loren McManus of the Sioux Falls Police Department, a vehicle headed south on Minnesota Avenue may have hit a northbound vehicle, before swerving into two more vehicles and lastly hitting a motorcycle.
The drivers of the vehicle that started the chain reaction, or the "striking vehicle," and the motorcycle were taken to a Sioux Falls hospital. Police were unable to disclose the conditions of the drivers or any further details.
Traffic Services officers remained on scene throughout Wednesday evening, gathering evidence and trying to definitively piece together how the accident happened.