These drugs are sold with seemingly harmless names like Spice, K2, NightLights, Rave and Snow Blind, but everything is not always what it seems.
Brendan Johnson, U.S. Attorney for South Dakota said "the products are often marketed as such things as Bath Salts, Plant Food, Shoe Deodorizer, Lady Bug attractant and sexual stimulants."
Last month, law enforcement worked together to crack down on the sellers, manufacturers, and distributors of dangerous fake drugs, known as analog or synthetic drugs.
"The effect of these analog drugs is similar to what we see with LSD, methamphetamine, cocaine, ecstasy," Johnson said.
Because these drugs can cause heart attacks, strokes or psychotic events, John had a strong warning for sellers, manufacturers and distributors.
"What you are doing is not only wrong, but illegal. And together from a state as well as a federal perspective, all of us are going to do everything in our power to shut you down," Johnson said.
The smoke shop Roll With It was the only store of it's kind targeted in Sioux Falls during Operation Log Jam.
On the same day the Department of Justice warns users and sellers about the dangers of synthetic and analog drugs, Roll with it was back in business.
Brendan could not confirm if the investigation is still on, but so far, no one has been arrested in Sioux Falls as part of Operation Log Jam.