The St. Jude Children's Research Hospital helps treat kids across the nation who are suffering from life-threatening diseases.
More than 300 video game streamers are "playing for more than bragging rights" to help raise money for the organization.
"Saint Jude Children's Hospital makes sure that the kids and their families, they don't have to worry about things like cost. It's an all encompassing thing to take care of the children," said Josh Mayer, an avid gamer.
Josh Mayer is from Aberdeen, he and his friends have made it a friendly competition.
"We're seeing who can raise the most money, but it's all for a good cause, the things St. Jude does is just phenomenal," Mayer said.
Many video game players are putting a lot of work into this campaign.
There are different incentives used to encourage donations.
"Absolutely, one of mine is that at $3,000 I'm going to die my beard purple," Mayer said.
All of the money raised will be used to help the kids, their families and the St. Jude mission.
"They operate off of donations from people, just out of the kindness of their hearts and the St. Jude Charity Drive, St Jude Play Live," Mayer said.
The mission means so much to Josh, a father of three, because it's hard for him to imagine what the children and families are going through.
"This charity is incredible and that's why I'm trying to raise awareness and money," said Mayer.
The annual event has raised more than 12 million dollars since it started.